CP466722

Across CCLE and GDSC cell-line panels, response to CP466722 is significantly associated with the total protein of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible CP466722 response-associated proteins across cancer lineages are Raptor, mTOR, and AMPK_pT172, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, CP466722 response versus Raptor total protein in BONE (Pearson r = 0.73).

Total protein biomarkers of CP466722 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Raptor →	+0.591	+1.478	<.001	<.001	3	6
OESOPHAGUS	mTOR →	+0.798	+0.633	.001	.012	3	5
LIVER	AMPK_pT172 →	+0.761	+0.887	.013	.025	3	5
LIVER	Cyclin-D1 →	-0.609	-0.927	.036	.013	2	6
STOMACH	MSH2 →	+0.483	+0.484	.018	.039	3	5
BONE	Bcl-2 →	+1.142	+1.512	.034	.001	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CP466722 response vs Raptor — BONE

Explore this scatter interactively →