CHIR-99021

Across CCLE and GDSC cell-line panels, response to CHIR-99021 is significantly associated with the mutation status of multiple genes, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible CHIR-99021 response-associated genes across cancer lineages are HMCN1, RANBP2, and PAK5, each associated with drug response in up to 1 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, CHIR-99021 response grouped by HMCN1 status in LUNG_SCLC.

Mutation status biomarkers of CHIR-99021 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	HMCN1 →	+1.959	+0.463	.023	.010	3	1
SKIN	RANBP2 →	-2.700	-0.448	.032	.020	3	1
SKIN	PAK5 →	-2.700	-0.508	.032	.007	3	1
SKIN	DNAH11 →	-2.584	-0.388	.049	.029	3	1
SKIN	DNAH6 →	-2.700	-0.405	.032	.037	3	1
LUNG_SCLC	MUC19 →	-2.655	-0.442	.019	.017	3	1

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHIR-99021 response by HMCN1 status — LUNG_SCLC

Explore this box plot interactively →