CHIR-99021

Across CCLE and GDSC cell-line panels, response to CHIR-99021 is significantly associated with the shRNA pathway dependency of multiple pathways, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible CHIR-99021 response-associated pathways across cancer lineages are rRNA catabolic process, Regulation of metaphase plate congression, and Kidney epithelium development, each associated with drug response in up to 5 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, CHIR-99021 response versus rRNA catabolic process shRNA pathway dependency in SKIN (Pearson r = 0.85).

Shrna pathway dependency biomarkers of CHIR-99021 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	rRNA catabolic process →	+0.340	+1.020	.012	.002	3	4
LUNG_NSCLC_LUAD	Regulation of metaphase plate congression →	-0.098	-0.775	.032	.022	3	4
BREAST	Kidney epithelium development →	-1.846	-0.229	.006	.044	2	5
BLOOD_Leukemia	Serotonin transport →	-2.157	-1.474	.003	.038	3	4
SKIN	Branched-chain amino acid transport →	+1.085	+0.821	.017	.004	3	3
SKIN	Response to glycoprotein →	+1.091	+1.020	.009	.002	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CHIR-99021 response vs rRNA catabolic process — SKIN

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