CGP-60474

Across CCLE and GDSC cell-line panels, response to CGP-60474 is significantly associated with the pathway activity of multiple pathways, with CNS cell lines showing a particularly strong set of associations.

The most reproducible CGP-60474 response-associated pathways across cancer lineages are Blastocyst formation, Ventricular cardiac muscle cell action potential, and Response to platinum ion, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, CGP-60474 response versus Blastocyst formation pathway activity in CNS (Pearson r = 0.67).

Pathway activity biomarkers of CGP-60474 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Blastocyst formation →	+0.125	+0.832	.017	.002	3	6
BLOOD_Myeloma	Ventricular cardiac muscle cell action potential →	-0.137	-0.443	.018	.029	3	5
LUNG_NSCLC_LUAD	Response to platinum ion →	+0.111	+1.463	.032	.042	3	5
CNS	Blastocyst development →	+0.137	+0.832	.009	.002	3	5
BREAST	Nucleobase-containing small molecule catabolic process →	+0.124	+1.299	.039	.006	3	5
OESOPHAGUS	RNA methylation →	-0.083	-0.721	.011	.030	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CGP-60474 response vs Blastocyst formation — CNS

Explore this scatter interactively →