CDK9_5576

Across CCLE and GDSC cell-line panels, response to CDK9_5576 is significantly associated with the shRNA dependency of multiple gene dependencies, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible CDK9_5576 response-associated gene dependencies across cancer lineages are HORMAD1, ESX1, and KATNA1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, CDK9_5576 response versus HORMAD1 shRNA dependency in BLOOD_Leukemia (Pearson r = 0.94).

Shrna dependency biomarkers of CDK9_5576 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HORMAD1 →	+0.203	+0.471	<.001	.001	3	8
BLOOD_Leukemia	ESX1 →	+0.232	+0.444	.015	.005	3	8
BLOOD_Leukemia	KATNA1 →	+0.239	+0.446	.018	.003	3	7
URINARY_TRACT	HBG1 →	+0.232	+1.453	.001	.010	3	7
UPPER_AERODIGESTIVE_TRACT	SERINC1 →	-0.312	-0.334	.018	.043	3	7
LUNG_SCLC	ARHGAP26 →	+0.202	+0.822	.026	.047	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDK9_5576 response vs HORMAD1 — BLOOD_Leukemia

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