CDK9_5576

Across CCLE and GDSC cell-line panels, response to CDK9_5576 is significantly associated with the shRNA pathway dependency of multiple pathways, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible CDK9_5576 response-associated pathways across cancer lineages are Acylglycerol transport, Triglyceride transport, and Mechanosensory behavior, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, CDK9_5576 response versus Acylglycerol transport shRNA pathway dependency in BLOOD_Leukemia (Pearson r = 0.56).

Shrna pathway dependency biomarkers of CDK9_5576 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Acylglycerol transport →	+1.608	+0.456	.001	.037	3	8
BLOOD_Leukemia	Triglyceride transport →	+1.608	+0.456	.001	.037	3	8
PANCREAS	Mechanosensory behavior →	+1.467	+0.627	.002	.012	3	7
PANCREAS	Learned vocalization behavior or vocal learning →	+1.467	+0.627	.002	.012	3	7
PANCREAS	Auditory behavior →	+1.467	+0.627	.002	.012	3	7
STOMACH	Regulation of platelet-derived growth factor receptor-alpha signaling pathway →	-1.377	-0.625	.021	.003	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDK9_5576 response vs Acylglycerol transport — BLOOD_Leukemia

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