CCT245232

Across CCLE and GDSC cell-line panels, response to CCT245232 is significantly associated with the shRNA dependency of multiple gene dependencies, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible CCT245232 response-associated gene dependencies across cancer lineages are CABP1, MSH2, and RASA3, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, CCT245232 response versus CABP1 shRNA dependency in PANCREAS (Pearson r = -0.47).

Shrna dependency biomarkers of CCT245232 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CABP1 →	-0.223	-0.468	.006	.002	3	8
LUNG_SCLC	MSH2 →	-0.216	-0.807	.019	.005	3	7
OVARY	RASA3 →	-0.256	-0.719	.019	.002	3	7
OVARY	ROS1 →	-0.195	-0.404	.037	.032	3	7
SKIN	KBTBD2 →	+0.147	+0.382	.012	.007	3	7
SOFT_TISSUE	PTGR1 →	+0.303	+0.403	.005	.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCT245232 response vs CABP1 — PANCREAS

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