CCT245232

Across CCLE and GDSC cell-line panels, response to CCT245232 is significantly associated with the total protein of multiple proteins, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible CCT245232 response-associated proteins across cancer lineages are Caveolin-1, E-Cadherin, and 14-3-3_beta, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, CCT245232 response versus Caveolin-1 total protein in BREAST (Pearson r = 0.36).

Total protein biomarkers of CCT245232 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Caveolin-1 →	+2.388	+0.389	.008	.008	3	8
LARGE_INTESTINE	E-Cadherin →	-2.263	-0.775	<.001	.002	3	6
OVARY	14-3-3_beta →	-0.272	-0.753	.010	.018	3	5
KIDNEY	P-Cadherin →	-0.636	-0.649	.009	.017	3	5
LARGE_INTESTINE	alpha-Catenin →	-0.787	-0.717	<.001	<.001	3	5
OVARY	c-Jun_pS73 →	+0.495	+0.661	.010	.002	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCT245232 response vs Caveolin-1 — BREAST

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