CCT245232

Across CCLE and GDSC cell-line panels, response to CCT245232 is significantly associated with the shRNA pathway dependency of multiple pathways, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible CCT245232 response-associated pathways across cancer lineages are Subpallium development, Striatum development, and Poly-N-acetyllactosamine metabolic process, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, CCT245232 response versus Subpallium development shRNA pathway dependency in LUNG_NSCLC_LUAD (Pearson r = -0.28).

Shrna pathway dependency biomarkers of CCT245232 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Subpallium development →	-0.529	-0.473	.032	.007	3	8
LUNG_NSCLC_LUAD	Striatum development →	-0.529	-0.473	.032	.007	3	8
PANCREAS	Poly-N-acetyllactosamine metabolic process →	+1.620	+0.629	.003	.009	3	7
BLOOD_Lymphoma	Negative regulation of chemokine (C-C motif) ligand 5 production →	-1.519	-1.093	<.001	.006	3	7
BLOOD_Leukemia	Lactam metabolic process →	+1.571	+0.614	.001	.001	3	7
PANCREAS	Establishment of protein localization to organelle →	-0.147	-0.320	.004	.003	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCT245232 response vs Subpallium development — LUNG_NSCLC_LUAD

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