CCT007093

Across CCLE and GDSC cell-line panels, response to CCT007093 is significantly associated with the protein-level pathway activity of multiple pathways, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible CCT007093 response-associated pathways across cancer lineages are Free ubiquitin chain polymerization, Negative regulation of signal transduction in absence of ligand, and Regulation of extrinsic apoptotic signaling pathway, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, CCT007093 response versus Free ubiquitin chain polymerization protein-level pathway activity in STOMACH (Pearson r = 0.55).

Protein-level pathway activity biomarkers of CCT007093 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Free ubiquitin chain polymerization →	+1.675	+0.491	<.001	.004	3	11
STOMACH	Negative regulation of signal transduction in absence of ligand →	-1.080	-0.377	.019	.031	3	10
BONE	Regulation of extrinsic apoptotic signaling pathway →	-0.294	-0.356	.003	.003	3	10
STOMACH	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand →	-1.080	-0.377	.019	.031	3	10
SOFT_TISSUE	Positive regulation of mRNA processing →	+0.247	+0.431	<.001	<.001	3	10
LUNG_NSCLC_LUSC	Regulation of protein localization to plasma membrane →	-0.230	-0.378	.037	.043	2	10

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CCT007093 response vs Free ubiquitin chain polymerization — STOMACH

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