CAY10603

Across CCLE and GDSC cell-line panels, response to CAY10603 is significantly associated with the protein-level pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible CAY10603 response-associated pathways across cancer lineages are Positive regulation of vasculature development, Porphyrin-containing compound metabolic process, and Cell-cell adhesion mediated by integrin, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, CAY10603 response versus Positive regulation of vasculature development protein-level pathway activity in BONE (Pearson r = -0.46).

Protein-level pathway activity biomarkers of CAY10603 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of vasculature development →	-0.330	-1.287	<.001	.002	3	8
LUNG_NSCLC_LUSC	Porphyrin-containing compound metabolic process →	-0.228	-0.610	.013	.010	3	8
BONE	Cell-cell adhesion mediated by integrin →	-0.293	-1.258	.015	.022	3	8
SOFT_TISSUE	Membrane disassembly →	+1.333	+1.323	.009	.013	3	8
SOFT_TISSUE	Nuclear membrane disassembly →	+1.333	+1.323	.009	.013	3	8
BONE	Positive regulation of hemostasis →	+0.653	+1.202	.023	.004	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CAY10603 response vs Positive regulation of vasculature development — BONE

Explore this scatter interactively →