C-75

Across CCLE and GDSC cell-line panels, response to C-75 is significantly associated with the mutation status of multiple genes, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible C-75 response-associated genes across cancer lineages are ZFHX4, ABCA1, and MUC4, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, C-75 response grouped by ZFHX4 status in SKIN.

Mutation status biomarkers of C-75 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZFHX4 →	+3.000	+0.374	.011	.006	3	3
LUNG_NSCLC_LUAD	ABCA1 →	+2.684	+0.410	.048	.003	3	3
LUNG_NSCLC_LUAD	MUC4 →	+2.169	+0.311	.020	.003	3	3
LUNG_SCLC	UNC13C →	+2.228	+0.396	.018	.007	3	3
LUNG_SCLC	UNC80 →	-2.691	-0.309	.030	.021	3	3
BLOOD_Leukemia	CMYA5 →	+1.623	+0.261	.009	.030	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

C-75 response by ZFHX4 status — SKIN

Explore this box plot interactively →