Bryostatin 1

Across CCLE and GDSC cell-line panels, response to Bryostatin 1 is significantly associated with the protein-level pathway activity of multiple pathways, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible Bryostatin 1 response-associated pathways across cancer lineages are Regulation of transcription by RNA polymerase I, Neurotrophin signaling pathway, and G protein-coupled dopamine receptor signaling pathway, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Bryostatin 1 response versus Regulation of transcription by RNA polymerase I protein-level pathway activity in BREAST (Pearson r = 0.39).

Protein-level pathway activity biomarkers of Bryostatin 1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Regulation of transcription by RNA polymerase I →	+0.268	+0.410	.001	.012	3	8
PANCREAS	Neurotrophin signaling pathway →	+0.676	+0.360	.040	.010	3	7
LUNG_NSCLC_LUAD	G protein-coupled dopamine receptor signaling pathway →	-0.142	-0.277	.005	.043	3	7
BREAST	Positive regulation of transcription by RNA polymerase I →	+0.252	+0.435	.012	.004	3	6
LIVER	Phagosome-lysosome fusion →	-0.179	-0.333	.027	.035	1	8
PANCREAS	2-oxoglutarate decarboxylation to succinyl-CoA →	-0.141	-0.271	<.001	.017	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Bryostatin 1 response vs Regulation of transcription by RNA polymerase I — BREAST

Explore this scatter interactively →