Brivanib

Across CCLE and GDSC cell-line panels, response to Brivanib is significantly associated with the protein abundance of multiple proteins, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible Brivanib response-associated proteins across cancer lineages are MCM6, MCM4, and BYSL, each associated with drug response in up to 12 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Brivanib response versus MCM6 protein abundance in SOFT_TISSUE (Pearson r = 0.58).

Protein abundance biomarkers of Brivanib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	MCM6 →	+1.526	+0.631	.020	.040	3	12
PANCREAS	MCM4 →	+1.011	+0.232	.003	.032	3	11
PANCREAS	BYSL →	+0.628	+0.288	<.001	.006	3	11
PANCREAS	GSTK1 →	-1.603	-0.407	.006	.005	3	11
SOFT_TISSUE	MCM2 →	+1.306	+0.599	.018	.046	3	11
LUNG_NSCLC_LUSC	IK →	+0.384	+0.432	.018	.011	3	10

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Brivanib response vs MCM6 — SOFT_TISSUE

Explore this scatter interactively →