Bosutinib

Across CCLE and GDSC cell-line panels, response to Bosutinib is significantly associated with the shRNA dependency of multiple gene dependencies, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible Bosutinib response-associated gene dependencies across cancer lineages are ATP6V1A, PLPP4, and FST, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Bosutinib response versus ATP6V1A shRNA dependency in BREAST (Pearson r = 0.32).

Shrna dependency biomarkers of Bosutinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ATP6V1A →	+0.315	+0.497	.015	.008	2	9
CNS	PLPP4 →	+0.282	+0.487	.016	.002	3	7
CNS	FST →	+0.221	+0.627	.002	.001	3	7
PANCREAS	SERINC1 →	-0.147	-0.605	.010	.001	3	7
PANCREAS	GALK1 →	-0.240	-0.612	.002	.008	2	7
LUNG_NSCLC_LUAD	KRT85 →	+0.203	+0.642	.002	.002	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Bosutinib response vs ATP6V1A — BREAST

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