Bleomycin

Across CCLE and GDSC cell-line panels, response to Bleomycin is significantly associated with the mutation status of multiple genes, with BLOOD_Myeloma cell lines showing a particularly strong set of associations.

The most reproducible Bleomycin response-associated genes across cancer lineages are TNXB, LAMA5, and FAT2, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, Bleomycin response grouped by TNXB status in BLOOD_Myeloma.

Mutation status biomarkers of Bleomycin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TNXB →	+2.584	+0.375	.029	.038	3	3
LUNG_SCLC	LAMA5 →	+2.643	+0.506	.042	.002	3	3
LUNG_NSCLC_LUAD	FAT2 →	+2.807	+0.584	.035	.035	3	3
STOMACH	RNF213 →	+2.584	+0.603	.015	.021	3	3
STOMACH	LRP2 →	+2.584	+0.703	.015	.007	3	3
BLOOD_Leukemia	MAST1 →	+2.684	+0.266	.035	.025	3	3

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Bleomycin response by TNXB status — BLOOD_Myeloma

Explore this box plot interactively →