Bleomycin

Across CCLE and GDSC cell-line panels, response to Bleomycin is significantly associated with the protein-level pathway activity of multiple pathways, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible Bleomycin response-associated pathways across cancer lineages are Negative regulation of proteasomal protein catabolic process, Negative regulation of neuron apoptotic process, and Negative regulation of proteasomal ubiquitin-dependent protein catabolic process, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Bleomycin response versus Negative regulation of proteasomal protein catabolic process protein-level pathway activity in OVARY (Pearson r = 0.30).

Protein-level pathway activity biomarkers of Bleomycin response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of proteasomal protein catabolic process →	+0.307	+0.736	.008	.013	3	8
BLOOD_Lymphoma	Negative regulation of neuron apoptotic process →	-0.228	-0.595	.007	<.001	3	8
OVARY	Negative regulation of proteasomal ubiquitin-dependent protein catabolic process →	+0.293	+0.654	.011	.026	3	7
BONE	Regulation of protein processing →	-0.356	-0.672	.014	.009	3	7
URINARY_TRACT	Cellular response to xenobiotic stimulus →	-0.336	-0.735	.002	.036	3	7
BLOOD_Leukemia	Relaxation of cardiac muscle →	-0.369	-0.247	.036	.042	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Bleomycin response vs Negative regulation of proteasomal protein catabolic process — OVARY

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