Bleomycin (50 uM)

Across CCLE and GDSC cell-line panels, response to Bleomycin (50 uM) is significantly associated with the shRNA pathway dependency of multiple pathways, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Bleomycin (50 uM) response-associated pathways across cancer lineages are Response to transition metal nanoparticle, Endoplasmic reticulum to Golgi vesicle-mediated transport, and Mucus secretion, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Bleomycin (50 uM) response versus Response to transition metal nanoparticle shRNA pathway dependency in LUNG_SCLC (Pearson r = 0.65).

Shrna pathway dependency biomarkers of Bleomycin (50 uM) response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Response to transition metal nanoparticle →	+1.771	+1.234	<.001	.028	3	8
LUNG_NSCLC_LUAD	Endoplasmic reticulum to Golgi vesicle-mediated transport →	-0.149	-0.794	.018	.027	3	8
STOMACH	Mucus secretion →	+0.866	+1.100	.039	.017	3	8
LUNG_SCLC	Regulation of neuron projection regeneration →	+1.340	+1.106	.003	.014	3	7
OVARY	Plus-end-directed vesicle transport along microtubule →	+2.168	+2.290	<.001	<.001	3	7
OVARY	Plus-end-directed organelle transport along microtubule →	+1.724	+1.756	<.001	.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Bleomycin (50 uM) response vs Response to transition metal nanoparticle — LUNG_SCLC

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