Bexarotene

Across CCLE and GDSC cell-line panels, response to Bexarotene is significantly associated with the protein abundance of multiple proteins, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Bexarotene response-associated proteins across cancer lineages are UTP18, IPO7, and SPTLC1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Bexarotene response versus UTP18 protein abundance in LUNG_SCLC (Pearson r = 0.47).

Protein abundance biomarkers of Bexarotene response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	UTP18 →	+0.528	+0.409	.021	.014	3	8
LUNG_NSCLC_LUSC	IPO7 →	+0.974	+0.932	.029	.005	3	7
LUNG_NSCLC_LUSC	SPTLC1 →	-0.848	-0.906	.024	.010	3	7
LIVER	MYADM →	-1.499	-0.750	.001	.024	3	7
PANCREAS	NAP1L1 →	+1.762	+0.558	.027	.043	2	8
PANCREAS	PCBP2 →	+1.155	+0.811	.025	.005	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Bexarotene response vs UTP18 — LUNG_SCLC

Explore this scatter interactively →