Belinostat

Across CCLE and GDSC cell-line panels, response to Belinostat is significantly associated with the protein-level pathway activity of multiple pathways, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible Belinostat response-associated pathways across cancer lineages are Motor behavior, tRNA wobble base modification, and Regulation of cell fate specification, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Belinostat response versus Motor behavior protein-level pathway activity in BLOOD_Leukemia (Pearson r = 0.48).

Protein-level pathway activity biomarkers of Belinostat response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Motor behavior →	+0.835	+0.321	<.001	<.001	3	8
BONE	tRNA wobble base modification →	+0.531	+0.904	.047	.033	3	7
PANCREAS	Regulation of cell fate specification →	+1.020	+0.661	.006	.005	3	7
BONE	Dephosphorylation →	+0.617	+0.856	.019	.013	3	7
BONE	Negative regulation of developmental growth →	-0.202	-0.971	.018	.026	3	7
BLOOD_Leukemia	Regulation of metaphase/anaphase transition of cell cycle →	+0.621	+0.365	<.001	<.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Belinostat response vs Motor behavior — BLOOD_Leukemia

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