BX795

Across CCLE and GDSC cell-line panels, response to BX795 is significantly associated with the mutation status of multiple genes, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible BX795 response-associated genes across cancer lineages are LRP2 and PKD1, each associated with drug response in up to 1 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, BX795 response grouped by LRP2 status in SKIN.

Mutation status biomarkers of BX795 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	LRP2 →	+2.129	+0.407	.036	.048	3	1
BLOOD_Leukemia	PKD1 →	-2.415	-0.517	.049	.042	3	1

Each biomarker links to its Q-omics profile. Showing the 2 strongest associations by consensus.

BX795 response by LRP2 status — SKIN

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