BPTES

Across CCLE and GDSC cell-line panels, response to BPTES is significantly associated with the pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible BPTES response-associated pathways across cancer lineages are Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator, and Negative regulation of Notch signaling pathway, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BPTES response versus Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) pathway activity in BONE (Pearson r = 0.33).

Pathway activity biomarkers of BPTES response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.147	+0.380	.040	.011	3	7
PANCREAS	Negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	+0.089	+0.724	.002	.010	3	7
BREAST	Negative regulation of Notch signaling pathway →	-0.081	-0.520	.002	<.001	3	7
OVARY	Subtelomeric heterochromatin formation →	+0.068	+0.522	.016	.004	3	7
LUNG_SCLC	Microtubule depolymerization →	+0.126	+0.426	.001	.010	3	7
BONE	Steroid hormone secretion →	-1.604	-0.686	<.001	<.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BPTES response vs Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) — BONE

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