BPD-00008900

Across CCLE and GDSC cell-line panels, response to BPD-00008900 is significantly associated with the protein abundance of multiple proteins, with UPPER_AERODIGESTIVE_TRACT cell lines showing a particularly strong set of associations.

The most reproducible BPD-00008900 response-associated proteins across cancer lineages are RPL38, RANGAP1, and BOP1, each associated with drug response in up to 10 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BPD-00008900 response versus RPL38 protein abundance in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.54).

Protein abundance biomarkers of BPD-00008900 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	RPL38 →	+0.896	+0.651	.002	.001	3	10
PANCREAS	RANGAP1 →	+0.729	+0.475	.001	.002	3	9
SOFT_TISSUE	BOP1 →	+0.726	+0.623	.004	.015	3	9
LUNG_SCLC	RPL5 →	+0.609	+0.345	.004	.011	3	9
BLOOD_Leukemia	RPS3 →	+0.432	+0.383	.002	.018	3	9
BLOOD_Myeloma	BAD →	-1.432	-0.652	.016	.044	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BPD-00008900 response vs RPL38 — UPPER_AERODIGESTIVE_TRACT

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