BMS-509744

Across CCLE and GDSC cell-line panels, response to BMS-509744 is significantly associated with the shRNA pathway dependency of multiple pathways, with BLOOD_Myeloma cell lines showing a particularly strong set of associations.

The most reproducible BMS-509744 response-associated pathways across cancer lineages are L-threonine metabolic process, L-threonine catabolic process, and Columnar/cuboidal epithelial cell differentiation, each associated with drug response in up to 5 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BMS-509744 response versus L-threonine metabolic process shRNA pathway dependency in BLOOD_Myeloma (Pearson r = 0.66).

Shrna pathway dependency biomarkers of BMS-509744 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	L-threonine metabolic process →	+1.424	+0.412	.031	.005	3	5
BLOOD_Myeloma	L-threonine catabolic process →	+1.424	+0.412	.031	.005	3	5
LUNG_NSCLC_LUAD	Columnar/cuboidal epithelial cell differentiation →	-0.401	-0.921	.011	.020	3	5
LUNG_NSCLC_LUAD	Regulation of Golgi inheritance →	+1.822	+1.230	<.001	<.001	3	5
CNS	DNA replication →	-0.396	-0.692	<.001	.049	3	5
CNS	DNA-templated DNA replication →	-0.356	-0.692	.001	.049	3	5

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMS-509744 response vs L-threonine metabolic process — BLOOD_Myeloma

Explore this scatter interactively →