BMS-345541

Across CCLE and GDSC cell-line panels, response to BMS-345541 is significantly associated with the protein abundance of multiple proteins, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible BMS-345541 response-associated proteins across cancer lineages are CDC73, RTN4, and POLR2C, each associated with drug response in up to 11 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BMS-345541 response versus CDC73 protein abundance in STOMACH (Pearson r = 0.55).

Protein abundance biomarkers of BMS-345541 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CDC73 →	+0.645	+0.833	.003	<.001	3	11
BONE	RTN4 →	-1.578	-0.368	<.001	.013	3	10
LARGE_INTESTINE	POLR2C →	+0.402	+0.705	.001	.006	3	10
BONE	ZFPL1 →	-1.019	-0.520	<.001	<.001	3	10
BONE	PICALM →	-1.180	-0.527	<.001	.002	3	10
BONE	MCM4 →	+1.290	+0.666	.002	.003	3	9

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMS-345541 response vs CDC73 — STOMACH

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