BMS-345541

Across CCLE and GDSC cell-line panels, response to BMS-345541 is significantly associated with the mutation status of multiple genes, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible BMS-345541 response-associated genes across cancer lineages are AHNAK, ABCA13, and FAT4, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, BMS-345541 response grouped by AHNAK status in BLOOD_Leukemia.

Mutation status biomarkers of BMS-345541 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	AHNAK →	-1.874	-0.177	.025	.029	3	3
BLOOD_Leukemia	ABCA13 →	-1.526	-0.231	.019	.005	3	3
BLOOD_Leukemia	FAT4 →	-1.321	-0.205	.020	.006	3	3
LUNG_SCLC	LAMA2 →	-2.807	-0.412	.035	.007	3	2
URINARY_TRACT	PKD1 →	+2.491	+0.478	.049	.045	3	2
LUNG_NSCLC_LUAD	CSMD3 →	-1.459	-0.324	.040	.037	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BMS-345541 response by AHNAK status — BLOOD_Leukemia

Explore this box plot interactively →