BIBR-1532

Across CCLE and GDSC cell-line panels, response to BIBR-1532 is significantly associated with the shRNA dependency of multiple gene dependencies, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible BIBR-1532 response-associated gene dependencies across cancer lineages are HSPE1-MOB4, GHRHR, and OR10A2, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BIBR-1532 response versus HSPE1-MOB4 shRNA dependency in SOFT_TISSUE (Pearson r = 0.86).

Shrna dependency biomarkers of BIBR-1532 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	HSPE1-MOB4 →	+0.630	+0.756	.036	.001	3	9
PANCREAS	GHRHR →	-0.214	-0.388	.011	.012	3	7
UPPER_AERODIGESTIVE_TRACT	OR10A2 →	-0.150	-0.302	.043	.024	2	8
BLOOD_Lymphoma	MAP3K9 →	+0.359	+0.517	.010	.015	3	7
CNS	CCDC141 →	+0.206	+0.469	.002	.004	3	7
CNS	SLC22A7 →	-0.164	-0.515	.007	.010	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BIBR-1532 response vs HSPE1-MOB4 — SOFT_TISSUE

Explore this scatter interactively →