BIBF-1120

Across CCLE and GDSC cell-line panels, response to BIBF-1120 is significantly associated with the shRNA pathway dependency of multiple pathways, with STOMACH cell lines showing a particularly strong set of associations.

The most reproducible BIBF-1120 response-associated pathways across cancer lineages are Monoatomic anion transmembrane transport, Regulation of CD4-positive, alpha-beta T cell activation, and Regulation of cytokine activity, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BIBF-1120 response versus Monoatomic anion transmembrane transport shRNA pathway dependency in STOMACH (Pearson r = -0.40).

Shrna pathway dependency biomarkers of BIBF-1120 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	Monoatomic anion transmembrane transport →	-0.733	-1.149	.049	.008	3	7
LUNG_NSCLC_LUAD	Regulation of CD4-positive, alpha-beta T cell activation →	-1.100	-0.531	.001	.004	3	7
OESOPHAGUS	Regulation of cytokine activity →	-1.215	-0.605	.035	.004	3	6
STOMACH	Positive regulation of neutrophil chemotaxis →	-0.606	-1.321	.016	.001	3	6
LUNG_NSCLC_LUSC	Regulation of gastro-intestinal system smooth muscle contraction →	-1.377	-0.983	<.001	.045	2	7
LUNG_NSCLC_LUSC	Positive regulation of gastro-intestinal system smooth muscle contraction →	-1.377	-0.983	<.001	.045	2	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BIBF-1120 response vs Monoatomic anion transmembrane transport — STOMACH

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