BI-2536

Across CCLE and GDSC cell-line panels, response to BI-2536 is significantly associated with the shRNA dependency of multiple gene dependencies, with BLOOD_Lymphoma cell lines showing a particularly strong set of associations.

The most reproducible BI-2536 response-associated gene dependencies across cancer lineages are UNC119, CHD2, and AGTR1, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BI-2536 response versus UNC119 shRNA dependency in BLOOD_Lymphoma (Pearson r = -0.45).

Shrna dependency biomarkers of BI-2536 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	UNC119 →	-0.393	-0.368	.011	.004	3	8
OVARY	CHD2 →	+0.215	+1.010	.022	.013	3	8
PANCREAS	AGTR1 →	+0.138	+0.885	.001	.003	3	8
URINARY_TRACT	RNPS1 →	+0.530	+2.386	.021	.008	3	8
CNS	CTNNBL1 →	+0.461	+0.882	.025	.005	3	7
LIVER	RGPD4 →	-0.243	-1.469	.028	.012	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BI-2536 response vs UNC119 — BLOOD_Lymphoma

Explore this scatter interactively →