BI-2536

Across CCLE and GDSC cell-line panels, response to BI-2536 is significantly associated with the shRNA pathway dependency of multiple pathways, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible BI-2536 response-associated pathways across cancer lineages are Prostate gland morphogenesis, Prostate gland epithelium morphogenesis, and Ketone catabolic process, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BI-2536 response versus Prostate gland morphogenesis shRNA pathway dependency in SOFT_TISSUE (Pearson r = -0.76).

Shrna pathway dependency biomarkers of BI-2536 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Prostate gland morphogenesis →	-1.313	-0.715	.040	.030	3	8
SOFT_TISSUE	Prostate gland epithelium morphogenesis →	-1.313	-0.715	.040	.030	3	8
LUNG_NSCLC_LUSC	Ketone catabolic process →	+1.761	+0.893	<.001	.034	3	8
OVARY	Neutral lipid metabolic process →	+0.942	+1.227	.022	.015	3	8
OVARY	Acylglycerol metabolic process →	+0.942	+1.227	.022	.015	3	8
LUNG_NSCLC_LUAD	Late endosome to vacuole transport →	-0.320	-1.703	.002	<.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BI-2536 response vs Prostate gland morphogenesis — SOFT_TISSUE

Explore this scatter interactively →