BEN

Across CCLE and GDSC cell-line panels, response to BEN is significantly associated with the shRNA dependency of multiple gene dependencies, with SOFT_TISSUE cell lines showing a particularly strong set of associations.

The most reproducible BEN response-associated gene dependencies across cancer lineages are NT5E, BTD, and KCNJ11, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BEN response versus NT5E shRNA dependency in SOFT_TISSUE (Pearson r = -0.91).

Shrna dependency biomarkers of BEN response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	NT5E →	-0.311	-1.526	.018	.049	3	8
LUNG_SCLC	BTD →	+0.342	+1.726	.001	.011	3	8
SOFT_TISSUE	KCNJ11 →	+0.298	+1.046	.027	.044	2	8
PANCREAS	OR1G1 →	+0.277	+1.272	.026	.001	3	7
LUNG_SCLC	ESX1 →	+0.224	+1.716	.003	.005	3	7
BLOOD_Leukemia	SLC6A3 →	-0.177	-0.932	.005	.017	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BEN response vs NT5E — SOFT_TISSUE

Explore this scatter interactively →