BDP-00009066

Across CCLE and GDSC cell-line panels, response to BDP-00009066 is significantly associated with the shRNA pathway dependency of multiple pathways, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible BDP-00009066 response-associated pathways across cancer lineages are Regulation of odontogenesis, L-tryptophan catabolic process, and Liver development, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BDP-00009066 response versus Regulation of odontogenesis shRNA pathway dependency in LUNG_NSCLC_LUAD (Pearson r = 0.34).

Shrna pathway dependency biomarkers of BDP-00009066 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of odontogenesis →	+0.834	+0.512	.024	.037	3	8
BLOOD_Myeloma	L-tryptophan catabolic process →	+1.744	+0.440	.016	<.001	3	7
STOMACH	Liver development →	+0.282	+0.487	.005	.001	3	7
CNS	Response to redox state →	+1.145	+0.460	.011	.005	3	7
LIVER	Mitochondrial ATP transmembrane transport →	+1.968	+0.698	<.001	.011	3	7
SKIN	Regulation of natural killer cell activation →	+0.252	+0.555	.004	.012	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BDP-00009066 response vs Regulation of odontogenesis — LUNG_NSCLC_LUAD

Explore this scatter interactively →