BDF00022089a

Across CCLE and GDSC cell-line panels, response to BDF00022089a is significantly associated with the protein abundance of multiple proteins, with BONE cell lines showing a particularly strong set of associations.

The most reproducible BDF00022089a response-associated proteins across cancer lineages are EEF1E1, ITM2C, and EIF3L, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BDF00022089a response versus EEF1E1 protein abundance in BONE (Pearson r = 0.43).

Protein abundance biomarkers of BDF00022089a response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	EEF1E1 →	+0.548	+0.204	.004	.034	3	8
STOMACH	ITM2C →	-2.863	-0.383	.012	.043	3	8
LIVER	EIF3L →	+0.790	+0.247	.012	.013	3	7
LUNG_NSCLC_LUAD	MECP2 →	-0.908	-0.448	.004	.008	3	7
LUNG_NSCLC_LUAD	HAS1 →	+0.714	+0.240	.007	.024	3	7
PANCREAS	GART →	+1.224	+0.390	.017	.013	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BDF00022089a response vs EEF1E1 — BONE

Explore this scatter interactively →