BAY-MPS1

Across CCLE and GDSC cell-line panels, response to BAY-MPS1 is significantly associated with the total protein of multiple proteins, with BLOOD_Leukemia cell lines showing a particularly strong set of associations.

The most reproducible BAY-MPS1 response-associated proteins across cancer lineages are ASNS, ACC1, and alpha-Catenin, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BAY-MPS1 response versus ASNS total protein in BLOOD_Leukemia (Pearson r = 0.27).

Total protein biomarkers of BAY-MPS1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ASNS →	+1.084	+0.573	.017	.020	3	7
OVARY	ACC1 →	+1.159	+0.687	.001	.002	3	7
LARGE_INTESTINE	alpha-Catenin →	-0.754	-0.748	.005	.008	3	7
LIVER	mTOR_pS2448 →	-0.469	-1.016	.028	.014	3	7
LUNG_NSCLC_LUSC	PCNA →	+0.313	+1.003	.011	.014	3	7
STOMACH	eIF4G →	+1.233	+1.522	.005	.004	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAY-MPS1 response vs ASNS — BLOOD_Leukemia

Explore this scatter interactively →