BAY-HDAC11_4

Across CCLE and GDSC cell-line panels, response to BAY-HDAC11_4 is significantly associated with the shRNA dependency of multiple gene dependencies, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible BAY-HDAC11_4 response-associated gene dependencies across cancer lineages are PPP2CB, PPP1R16B, and DMGDH, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BAY-HDAC11_4 response versus PPP2CB shRNA dependency in PANCREAS (Pearson r = -0.52).

Shrna dependency biomarkers of BAY-HDAC11_4 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PPP2CB →	-0.186	-0.671	.008	.022	3	7
URINARY_TRACT	PPP1R16B →	+0.084	+0.605	.018	.013	2	7
URINARY_TRACT	DMGDH →	-0.310	-0.723	.034	.027	3	6
STOMACH	GRK5 →	+0.453	+1.193	.025	<.001	3	6
BLOOD_Myeloma	COL1A1 →	+0.180	+0.424	.006	.034	2	7
BLOOD_Myeloma	ZNF24 →	-0.450	-0.424	.001	.034	2	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAY-HDAC11_4 response vs PPP2CB — PANCREAS

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