BAY-HDAC11_4

Across CCLE and GDSC cell-line panels, response to BAY-HDAC11_4 is significantly associated with the pathway activity of multiple pathways, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible BAY-HDAC11_4 response-associated pathways across cancer lineages are Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay, Host-mediated suppression of viral transcription, and Host-mediated suppression of viral proces, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BAY-HDAC11_4 response versus Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay pathway activity in PANCREAS (Pearson r = 0.67).

Pathway activity biomarkers of BAY-HDAC11_4 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay →	+0.107	+0.717	.014	.005	3	8
KIDNEY	Host-mediated suppression of viral transcription →	+0.159	+0.632	.014	.009	2	9
KIDNEY	Host-mediated suppression of viral proces →	+0.197	+0.567	.005	.024	3	8
OVARY	Vasculogenesis →	-0.095	-0.487	.036	.018	3	8
STOMACH	Termination of RNA polymerase I transcription →	+0.120	+0.459	.009	.027	3	8
LUNG_NSCLC_LUSC	Negative regulation of intrinsic apoptotic signaling pathway →	-0.097	-0.500	.030	.029	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAY-HDAC11_4 response vs Negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay — PANCREAS

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