BAY-HDAC11_2

Across CCLE and GDSC cell-line panels, response to BAY-HDAC11_2 is significantly associated with the mutation status of multiple genes, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible BAY-HDAC11_2 response-associated genes across cancer lineages are TRIOBP, RYR2, and ABCA13, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, BAY-HDAC11_2 response grouped by TRIOBP status in LUNG_NSCLC_LUAD.

Mutation status biomarkers of BAY-HDAC11_2 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRIOBP →	-2.999	-0.443	.024	.012	3	3
URINARY_TRACT	RYR2 →	+2.321	+0.437	.047	.036	3	3
SKIN	ABCA13 →	+1.378	+0.270	.037	.015	3	3
LUNG_SCLC	LRRK2 →	-2.038	-0.427	.036	.040	3	2
LARGE_INTESTINE	AHNAK2 →	+2.754	+0.440	.015	.014	3	2
SKIN	CSMD1 →	+1.087	+0.306	.022	.003	3	2

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAY-HDAC11_2 response by TRIOBP status — LUNG_NSCLC_LUAD

Explore this box plot interactively →