BAY AKT1

Across CCLE and GDSC cell-line panels, response to BAY AKT1 is significantly associated with the pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible BAY AKT1 response-associated pathways across cancer lineages are HRI-mediated signaling, Regulation of vitamin D receptor signaling pathway, and Negative regulation of monocyte chemotactic protein-1 production, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BAY AKT1 response versus HRI-mediated signaling pathway activity in BONE (Pearson r = -0.44).

Pathway activity biomarkers of BAY AKT1 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	HRI-mediated signaling →	-0.146	-0.626	.005	.019	2	9
LIVER	Regulation of vitamin D receptor signaling pathway →	+0.329	+0.592	.005	.047	3	7
UPPER_AERODIGESTIVE_TRACT	Negative regulation of monocyte chemotactic protein-1 production →	+0.143	+0.382	.030	.039	3	7
SOFT_TISSUE	Positive regulation of apoptotic signaling pathway →	-0.110	-0.369	.002	.027	3	7
LIVER	Glandular epithelial cell differentiation →	+2.474	+0.783	<.001	.042	3	7
STOMACH	Regulation of programmed necrotic cell death →	-0.075	-1.098	.012	.028	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAY AKT1 response vs HRI-mediated signaling — BONE

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