BAY ACCi

Across CCLE and GDSC cell-line panels, response to BAY ACCi is significantly associated with the RNA expression of multiple genes, with SKIN cell lines showing a particularly strong set of associations.

The most reproducible BAY ACCi response-associated genes across cancer lineages are ASCC1, EBP, and SERTAD2, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BAY ACCi response versus ASCC1 RNA expression in SKIN (Pearson r = -0.30).

Rna expression biomarkers of BAY ACCi response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ASCC1 →	-0.342	-0.193	.039	.042	3	8
BREAST	EBP →	+1.010	+0.387	.001	.002	3	8
BONE	SERTAD2 →	-1.668	-0.556	<.001	.004	3	7
BONE	CMC4 →	-0.830	-0.547	.030	.010	3	7
LUNG_SCLC	PARP3 →	-1.500	-0.440	.016	.008	3	7
BONE	FOXJ2 →	-0.902	-0.565	.002	<.001	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAY ACCi response vs ASCC1 — SKIN

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