BAY-61-3606

Across CCLE and GDSC cell-line panels, response to BAY-61-3606 is significantly associated with the total protein of multiple proteins, with OVARY cell lines showing a particularly strong set of associations.

The most reproducible BAY-61-3606 response-associated proteins across cancer lineages are Bap1-c-4, 14-3-3_beta, and JAK2, each associated with drug response in up to 6 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, BAY-61-3606 response versus Bap1-c-4 total protein in OVARY (Pearson r = 0.51).

Total protein biomarkers of BAY-61-3606 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Bap1-c-4 →	+0.485	+0.726	.013	.013	3	6
UPPER_AERODIGESTIVE_TRACT	14-3-3_beta →	-0.322	-0.722	.043	.039	3	5
LIVER	JAK2 →	+0.716	+1.325	.004	.005	3	5
SKIN	FOXO3a_pS318_S321 →	-0.190	-0.867	.002	.006	3	5
CNS	mTOR_pS2448 →	-0.237	-0.297	.011	.028	3	5
LIVER	Mre11 →	+0.289	+0.817	.001	.012	3	4

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BAY-61-3606 response vs Bap1-c-4 — OVARY

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