Axitinib

Across CCLE and GDSC cell-line panels, response to Axitinib is significantly associated with the shRNA dependency of multiple gene dependencies, with PANCREAS cell lines showing a particularly strong set of associations.

The most reproducible Axitinib response-associated gene dependencies across cancer lineages are TBX22, NOCT, and SATB2, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Axitinib response versus TBX22 shRNA dependency in PANCREAS (Pearson r = 0.54).

Shrna dependency biomarkers of Axitinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TBX22 →	+0.334	+0.721	.019	.022	3	8
KIDNEY	NOCT →	+0.481	+0.220	.037	.027	3	7
UPPER_AERODIGESTIVE_TRACT	SATB2 →	+0.193	+0.950	.008	<.001	3	7
LIVER	RAC1 →	-0.555	-0.746	.024	.021	3	7
PANCREAS	IRAK1BP1 →	-0.167	-0.846	.033	.001	3	7
PANCREAS	FOXI1 →	-0.254	-0.713	.009	.015	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Axitinib response vs TBX22 — PANCREAS

Explore this scatter interactively →