Amuvatinib

Across CCLE and GDSC cell-line panels, response to Amuvatinib is significantly associated with the shRNA pathway dependency of multiple pathways, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible Amuvatinib response-associated pathways across cancer lineages are Maintenance of presynaptic active zone structure, Aerobic respiration, and Ascending aorta development, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Amuvatinib response versus Maintenance of presynaptic active zone structure shRNA pathway dependency in BREAST (Pearson r = -0.38).

Shrna pathway dependency biomarkers of Amuvatinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Maintenance of presynaptic active zone structure →	-1.158	-0.774	.001	.001	3	7
BREAST	Aerobic respiration →	+0.282	+0.890	.017	.006	3	7
CNS	Ascending aorta development →	+1.508	+1.298	.003	.001	3	7
CNS	Ascending aorta morphogenesis →	+1.508	+1.298	.003	.001	3	7
LUNG_NSCLC_LUSC	Cardiac ventricle formation →	+1.569	+0.564	.005	.039	3	6
LUNG_SCLC	Pteridine-containing compound biosynthetic process →	+1.604	+0.844	<.001	.021	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Amuvatinib response vs Maintenance of presynaptic active zone structure — BREAST

Explore this scatter interactively →