Afuresertib

Across CCLE and GDSC cell-line panels, response to Afuresertib is significantly associated with the shRNA dependency of multiple gene dependencies, with UPPER_AERODIGESTIVE_TRACT cell lines showing a particularly strong set of associations.

The most reproducible Afuresertib response-associated gene dependencies across cancer lineages are LHX1, YWHAE, and GJA3, each associated with drug response in up to 7 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Afuresertib response versus LHX1 shRNA dependency in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.59).

Shrna dependency biomarkers of Afuresertib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene dependencie	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	LHX1 →	+0.208	+0.627	.044	.034	3	7
BLOOD_Lymphoma	YWHAE →	+0.443	+1.693	.022	.039	3	6
LUNG_NSCLC_LUSC	GJA3 →	+0.278	+0.885	.032	.023	3	6
BLOOD_Myeloma	TNFRSF10B →	-0.309	-1.186	.034	.019	3	6
BLOOD_Myeloma	GDE1 →	-0.238	-0.849	.004	.032	3	6
LARGE_INTESTINE	HAO2 →	-0.241	-1.007	.005	.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Afuresertib response vs LHX1 — UPPER_AERODIGESTIVE_TRACT

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