Afatinib

Across CCLE and GDSC cell-line panels, response to Afatinib is significantly associated with the pathway activity of multiple pathways, with BONE cell lines showing a particularly strong set of associations.

The most reproducible Afatinib response-associated pathways across cancer lineages are Positive regulation of supramolecular fiber organization, Positive regulation of amyloid-beta clearance, and Keratinocyte development, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, Afatinib response versus Positive regulation of supramolecular fiber organization pathway activity in BONE (Pearson r = -0.54).

Pathway activity biomarkers of Afatinib response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of supramolecular fiber organization →	-0.070	-0.258	.020	.024	3	8
URINARY_TRACT	Positive regulation of amyloid-beta clearance →	-0.141	-0.631	.041	.047	2	9
LUNG_NSCLC_LUAD	Keratinocyte development →	-0.188	-0.672	.042	.026	3	8
BONE	Regulation of intracellular transport →	-0.064	-0.340	<.001	.044	3	7
SOFT_TISSUE	Regulation of cellular component size →	-0.060	-0.515	.010	.045	3	7
SOFT_TISSUE	Protein localization to endosome →	-0.118	-0.448	.044	.044	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Afatinib response vs Positive regulation of supramolecular fiber organization — BONE

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