Acetalax

Across CCLE and GDSC cell-line panels, response to Acetalax is significantly associated with the mutation status of multiple genes, with LUNG_SCLC cell lines showing a particularly strong set of associations.

The most reproducible Acetalax response-associated genes across cancer lineages are CSMD1, USH2A, and MUC4, each associated with drug response in up to 3 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The box plot shows the strongest observed association, Acetalax response grouped by CSMD1 status in LUNG_SCLC.

Mutation status biomarkers of Acetalax response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CSMD1 →	-2.584	-0.260	.040	.035	3	3
BLOOD_Lymphoma	USH2A →	-1.299	-0.239	.011	.020	3	2
STOMACH	MUC4 →	+2.584	+1.251	.015	<.001	2	3
LARGE_INTESTINE	NIBAN2 →	-1.672	-0.647	.047	.031	3	2
BLOOD_Lymphoma	CHD5 →	-2.807	-0.227	.039	.042	3	1
BLOOD_Lymphoma	OBSCN →	-1.791	-0.314	.003	.002	3	1

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Acetalax response by CSMD1 status — LUNG_SCLC

Explore this box plot interactively →