AZD8835

Across CCLE and GDSC cell-line panels, response to AZD8835 is significantly associated with the pathway activity of multiple pathways, with URINARY_TRACT cell lines showing a particularly strong set of associations.

The most reproducible AZD8835 response-associated pathways across cancer lineages are Lysosomal lumen pH elevation, Lactose metabolic process, and Vesicle transport along actin filament, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD8835 response versus Lysosomal lumen pH elevation pathway activity in URINARY_TRACT (Pearson r = -0.42).

Pathway activity biomarkers of AZD8835 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Lysosomal lumen pH elevation →	-0.236	-0.679	.013	.013	3	8
LIVER	Lactose metabolic process →	+0.247	+0.530	.018	.032	3	7
SOFT_TISSUE	Vesicle transport along actin filament →	-0.145	-0.664	.005	.013	3	7
LUNG_NSCLC_LUAD	Negative regulation of smooth muscle contraction →	+0.100	+0.316	.004	.003	3	7
BREAST	Relaxation of smooth muscle →	+0.224	+0.499	.001	.007	3	6
BREAST	Relaxation of vascular associated smooth muscle →	+0.173	+0.585	<.001	<.001	3	6

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD8835 response vs Lysosomal lumen pH elevation — URINARY_TRACT

Explore this scatter interactively →