AZD8055

Across CCLE and GDSC cell-line panels, response to AZD8055 is significantly associated with the protein-level pathway activity of multiple pathways, with LUNG_NSCLC_LUAD cell lines showing a particularly strong set of associations.

The most reproducible AZD8055 response-associated pathways across cancer lineages are Regulation of response to type II interferon, Regulation of type II interferon-mediated signaling pathway, and Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator, each associated with drug response in up to 8 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD8055 response versus Regulation of response to type II interferon protein-level pathway activity in LUNG_NSCLC_LUAD (Pearson r = 0.41).

Protein-level pathway activity biomarkers of AZD8055 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	Regulation of response to type II interferon →	+0.234	+0.675	.006	.007	3	8
LUNG_NSCLC_LUAD	Regulation of type II interferon-mediated signaling pathway →	+0.234	+0.675	.006	.007	3	8
LUNG_SCLC	Positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator →	+0.159	+0.743	.049	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of lamellipodium assembly →	+0.298	+1.041	.001	.002	3	7
LIVER	Regulation of lamellipodium organization →	+0.352	+0.802	.018	.033	3	7
OVARY	Protein neddylation →	+1.238	+0.510	.002	.014	3	7

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD8055 response vs Regulation of response to type II interferon — LUNG_NSCLC_LUAD

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