AZD7969

Across CCLE and GDSC cell-line panels, response to AZD7969 is significantly associated with the pathway activity of multiple pathways, with KIDNEY cell lines showing a particularly strong set of associations.

The most reproducible AZD7969 response-associated pathways across cancer lineages are Detection of mechanical stimulus involved in sensory perception of touch, Protein targeting to membrane, and Cotranslational protein targeting to membrane, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD7969 response versus Detection of mechanical stimulus involved in sensory perception of touch pathway activity in KIDNEY (Pearson r = -0.75).

Pathway activity biomarkers of AZD7969 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Detection of mechanical stimulus involved in sensory perception of touch →	-0.416	-0.897	.002	.011	3	9
LARGE_INTESTINE	Protein targeting to membrane →	-0.065	-0.790	<.001	.001	3	8
UPPER_AERODIGESTIVE_TRACT	Cotranslational protein targeting to membrane →	-0.128	-0.655	<.001	.002	3	8
PANCREAS	Negative regulation of glial cell proliferation →	-0.120	-0.424	.048	.013	2	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of endoplasmic reticulum unfolded protein response →	-0.123	-0.584	<.001	<.001	3	8
UPPER_AERODIGESTIVE_TRACT	Regulation of protein localization to membrane →	-0.096	-0.514	.001	.002	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD7969 response vs Detection of mechanical stimulus involved in sensory perception of touch — KIDNEY

Explore this scatter interactively →