AZD7969

Across CCLE and GDSC cell-line panels, response to AZD7969 is significantly associated with the protein-level pathway activity of multiple pathways, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible AZD7969 response-associated pathways across cancer lineages are U1 snRNA 3'-end processing, U5 snRNA 3'-end processing, and Nuclear polyadenylation-dependent rRNA catabolic process, each associated with drug response in up to 12 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD7969 response versus U1 snRNA 3'-end processing protein-level pathway activity in BREAST (Pearson r = 0.45).

Protein-level pathway activity biomarkers of AZD7969 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner pathway	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	U1 snRNA 3'-end processing →	+1.190	+0.649	<.001	.001	3	12
BREAST	U5 snRNA 3'-end processing →	+1.190	+0.649	<.001	.001	3	12
BONE	Nuclear polyadenylation-dependent rRNA catabolic process →	+1.649	+0.432	<.001	.025	3	11
BONE	TRAMP-dependent tRNA surveillance pathway →	+1.649	+0.432	<.001	.025	3	11
BREAST	Fatty acid catabolic process →	-0.185	-0.531	<.001	<.001	3	10
BREAST	Nuclear mRNA surveillance →	+1.344	+0.536	<.001	<.001	3	10

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD7969 response vs U1 snRNA 3'-end processing — BREAST

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