AZD7762

Across CCLE and GDSC cell-line panels, response to AZD7762 is significantly associated with the RNA expression of multiple genes, with BREAST cell lines showing a particularly strong set of associations.

The most reproducible AZD7762 response-associated genes across cancer lineages are TMEM9B, RRAGB, and GRIN2D, each associated with drug response in up to 9 lineages. Since the analysis identifies associations rather than directional relationships, both response-to-biomarker and biomarker-to-response views are provided.

Each biomarker is linked to its corresponding Q-omics profile. The scatter plot shows the strongest observed association, AZD7762 response versus TMEM9B RNA expression in BREAST (Pearson r = -0.40).

Rna expression biomarkers of AZD7762 response

Ranked by combined sampling and lineage consensus. X-score (response→biomarker) and Y-score (biomarker→response) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	TMEM9B →	-0.740	-0.991	.002	.010	3	9
UPPER_AERODIGESTIVE_TRACT	RRAGB →	-0.926	-0.571	.005	.009	3	9
BREAST	GRIN2D →	+1.141	+0.878	.011	.019	3	9
SOFT_TISSUE	GOSR2 →	-0.672	-0.567	.012	.025	2	9
PANCREAS	ANXA10 →	+2.913	+0.496	.023	.038	2	9
LIVER	LPAR6 →	-2.265	-1.121	.035	.001	3	8

Each biomarker links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AZD7762 response vs TMEM9B — BREAST

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